Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 3/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13606528 | 0.78 | CHEK1 (0.56) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4495900 | 0.70 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL11158275 | 0.68 | MMP12 (0.50) | CCNA2CDK2CCNA1LMNAHTT | |
| SCHEMBL28282944 | 0.67 | KDM4E (0.59) | CCNA2CDK2CCNA1KDM4ESMN1; SMN2 | |
| SCHEMBL19494296 | 0.65 | ALDH1A1 (0.63) | CHEK1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL3344759 | 0.64 | RXFP1 (0.52) | KMT2AMEN1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL34462305 | 0.64 | MERTK (0.81) | MERTKTYRO3GAS6TLR8TLR7 | |
| SCHEMBL4062438 | 0.63 | CYP3A4 (0.54) | KMT2AMEN1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL16435447 | 0.63 | MERTK (1.00) | MERTKTYRO3GAS6 | |
| SCHEMBL14447665 | 0.62 | JAK2 (0.43) | JAK2JAK1TYK2JAK3TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556053-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556053-A1 | ANTIINFLAMMATION AGENTS | Amgen Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041285-A1 | ANTIINFLAMMATION AGENTS | AMGEN INC. (US) | 2004-05-21 | — | — | WO | disclosed |