Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240902 | 0.86 | AKR1B1 (0.45) | AKR1B1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL4245618 | 0.77 | RAB9A (0.51) | AKR1B1KMT2AMEN1HPGDKDM4E | |
| SCHEMBL7586348 | 0.73 | PYGL (0.41) | AKR1B1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL29872269 | 0.72 | HPGD (0.46) | P2RX7KMT2AMEN1HPGDALOX15 | |
| SCHEMBL23755069 | 0.72 | HPGD (0.46) | P2RX7KMT2AMEN1HPGDALOX15 | |
| SCHEMBL6599217 | 0.72 | KMT2A (0.42) | P2RX7KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL18451321 | 0.70 | HPGD (0.50) | P2RX7KMT2AHPGDALOX15NPC1 | |
| SCHEMBL3097093 | 0.70 | SMN1; SMN2 (0.49) | AKR1B1KMT2AMEN1HPGDALOX15 | |
| SCHEMBL3322169 | 0.69 | PTPN1 (0.50) | P2RX7KMT2AHPGDALOX15NPC1 | |
| SCHEMBL9423079 | 0.69 | HPGD (0.49) | P2RX7KMT2AHPGDALOX15NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |