Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 4/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585660 | 0.84 | ADRB2 (0.44) | MAPTRAB9ACYP3A4ALDH1A1MEN1 | |
| SCHEMBL7584819 | 0.83 | ADRB2 (0.39) | MAPTCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8502095 | 0.80 | ROCK2 (0.39) | PYGLPLA2G2AMAPTRAB9ANPC1 | |
| SCHEMBL7590521 | 0.80 | HPGD (0.48) | MAPTCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7583126 | 0.80 | ADRB2 (0.39) | MAPTCYP3A4ALDH1A1GAAADRB2 | |
| SCHEMBL7583504 | 0.77 | ALDH1A1 (0.40) | MAPTCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7583097 | 0.74 | ALDH1A1 (0.41) | MAPTRAB9ANPC1CYP3A4CYP1A2 | |
| SCHEMBL8502094 | 0.74 | MEN1 (0.45) | PYGLPLA2G2AMAPTPTGER1ALDH1A1 | |
| SCHEMBL7276846 | 0.74 | PDE4A (0.45) | MAPTCYP1A2CYP2C9CYP2C19GAA | |
| Hydrochloric Acid SCHEMBL7274487 | 0.73 | PDE4A (0.44) | MAPTCYP1A2CYP2C9CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |