Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | IL1RN | P18510 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097925 | 0.83 | CYP19A1 (0.59) | PKMFFAR4TSHRALDH1A1HPGD | |
| SCHEMBL6073365 | 0.82 | KEAP1 (0.57) | PKMIL1RNKEAP1ERAP1FFAR4 | |
| SCHEMBL399983 | 0.80 | AKR1C3 (0.59) | TSHRMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL2568299 | 0.80 | RECQL (0.58) | IL1RNKEAP1ERAP1TSHRALDH1A1 | |
| SCHEMBL6760868 | 0.79 | RECQL (0.57) | PKMIL1RNKEAP1ERAP1TSHR | |
| SCHEMBL31681427 | 0.78 | FFAR4 (0.60) | PKMFFAR4TSHRALDH1A1MEN1 | |
| SCHEMBL5822638 | 0.78 | FFAR4 (0.72) | PKMIL1RNKEAP1ERAP1FFAR4 | |
| SCHEMBL10625562 | 0.77 | KEAP1 (0.46) | KEAP1TSHRALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL16830242 | 0.77 | TSHR (0.68) | KEAP1FFAR4TSHRALDH1A1KMT2A | |
| SCHEMBL6817587 | 0.76 | KEAP1 (0.56) | PKMIL1RNKEAP1ERAP1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651595-A2 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |