SCHEMBL8097925

SCHEMBL8097925

O=S(=O)(Nc1c(F)cccc1F)c1ccc(Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.59
CES1 P23141 1/20 0.56
FFAR4 Q5NUL3 1/20 0.56
ALDH1A1 P00352 3/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA3 P07451 1/20 0.53
CA4 P22748 1/20 0.53
CA6 P23280 1/20 0.53
CA5A P35218 1/20 0.53
CA7 P43166 1/20 0.53
CA9 Q16790 1/20 0.53
CA13 Q8N1Q1 1/20 0.53
CA14 Q9ULX7 1/20 0.53
CA5B Q9Y2D0 1/20 0.53
TSHR P16473 1/20 0.53
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5796892 0.83 PKM (0.57) FFAR4ALDH1A1TSHRHPGDKDM4E
SCHEMBL12396050 0.83 CES1 (0.62) CYP19A1CES1FFAR4ALDH1A1L3MBTL1
SCHEMBL28088443 0.80 APP (0.51) CYP19A1CES1FFAR4ALDH1A1CA12
SCHEMBL31681427 0.77 FFAR4 (0.60) FFAR4ALDH1A1L3MBTL1CA2TSHR
SCHEMBL16830242 0.76 TSHR (0.68) FFAR4ALDH1A1L3MBTL1CA12CA1
SCHEMBL6398759 0.75 CCR2 (0.64) CYP19A1CES1ALDH1A1LMNA
SCHEMBL14964574 0.73 APP (0.58) CES1ALDH1A1CA12CA1CA2
SCHEMBL3366221 0.73 CES1 (0.81) CYP19A1CES1FFAR4ALDH1A1CA1
SCHEMBL22095986 0.73 LMNA (0.52) ALDH1A1TSHRMAPTHPGDLMNA
SCHEMBL2474197 0.72 CES1 (1.00) CYP19A1CES1ALDH1A1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6114580-A N-arylsulfilimine compounds and their use as catalysts in the preparation of N-arylarylsulfonamide compounds DOW AGROSCIENCES LLC (US) 2000-09-05 US disclosed
EP-0888297-B1 N-ARYLSULFILIMINE COMPOUNDS AND THEIR USE AS CATALYSTS IN THE PREPARATION OF N-ARYLARYLSULFONAMIDE COMPOUNDS DOW AGROSCIENCES LLC (US) 2000-08-30 EP disclosed
US-5973148-A N-arylsulfilimine compounds and their use as catalysts in the preparation of N-arylarylsulfonamide compounds DOW AGROSCIENCES LLC (US) 1999-10-26 US disclosed