Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 5/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP10 | P09238 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049551 | 0.87 | TSHR (0.63) | TSHRLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4045604 | 0.78 | GLA (0.47) | TSHRGLA | |
| SCHEMBL4054011 | 0.75 | LMNA (0.51) | TSHRLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4046751 | 0.72 | DAO (0.52) | TSHRLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29125694 | 0.72 | RAB9A (0.51) | TSHRLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4047450 | 0.69 | DAO (0.47) | SMN1; SMN2DAOKMT2AHSD17B10 | |
| SCHEMBL5798854 | 0.68 | ALDH1A1 (0.34) | TSHRLMNASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL12474423 | 0.68 | DAO (0.73) | TSHRLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL29125953 | 0.66 | TSHR (0.54) | TSHRLMNAALDH1A1MMP13KMT2A | |
| SCHEMBL29125771 | 0.66 | KMT2A (0.54) | TSHRLMNANPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732903-A1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095362-A1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | ASTRAZENECA AB (SE) | 2005-10-13 | — | — | WO | disclosed |