Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 5/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249675 | 0.89 | MAPK11 (0.40) | MAPK11MAPK14MAPK13MAPK12OPRM1 | |
| SCHEMBL4247801 | 0.83 | MAPK11 (0.42) | MAPK11MAPK14MAPK13MAPK12OPRM1 | |
| SCHEMBL5808373 | 0.73 | POLB (0.34) | POLBCASP6GSK3BBACE1 | |
| SCHEMBL5798754 | 0.72 | PIM1 (0.40) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL4239808 | 0.65 | MAPK11 (0.46) | MAPK11MAPK14MAPK13MAPK12LMNA | |
| SCHEMBL4240705 | 0.63 | LMNA (0.47) | MAPK11MAPK14MAPK13MAPK12LMNA | |
| SCHEMBL19507134 | 0.63 | SMN1; SMN2 (0.44) | TSHRLMNAMAPK1POLBCASP6 | |
| SCHEMBL5795810 | 0.62 | MAPK11 (0.37) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL5797396 | 0.61 | MAPK14 (0.47) | MAPK11MAPK14MAPK13MAPK12CYP2C9 | |
| SCHEMBL18770748 | 0.60 | MAPK14 (0.41) | MAPK11MAPK14MAPK13MAPK12OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |