Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239808 | 0.89 | MAPK11 (0.46) | MAPK14MAPK11MAPK13MAPK12P2RX7 | |
| SCHEMBL4240705 | 0.82 | LMNA (0.47) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5796462 | 0.78 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12P2RX7 | |
| SCHEMBL5798754 | 0.78 | PIM1 (0.40) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL4236899 | 0.69 | MAPK11 (0.44) | MAPK14MAPK11MAPK13MAPK12P2RX7 | |
| SCHEMBL5796374 | 0.68 | AKR1B1 (0.46) | P2RX7 | |
| SCHEMBL3097093 | 0.67 | SMN1; SMN2 (0.49) | — | |
| SCHEMBL18781471 | 0.67 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5799285 | 0.67 | MAPK11 (0.63) | MAPK14MAPK11MAPK13MAPK12P2RX7 | |
| SCHEMBL4247801 | 0.67 | MAPK11 (0.42) | MAPK14MAPK11MAPK13MAPK12P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |