Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 12/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | PLD2 | O14939 | 7/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784756 | 0.92 | PLD1 (0.52) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL5779538 | 0.88 | OPRK1 (0.51) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL5782643 | 0.87 | OPRK1 (0.52) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL5780094 | 0.85 | CTSB (0.58) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL5781119 | 0.85 | PLD1 (0.50) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL6481466 | 0.81 | CTSB (0.57) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL5782996 | 0.79 | CTSB (0.53) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL5782410 | 0.78 | OPRL1 (0.47) | OPRK1OPRM1OPRD1OPRL1 | |
| SCHEMBL5783375 | 0.78 | CTSB (0.50) | PLD1OPRK1CTSBCTSSCTSK | |
| SCHEMBL6812370 | 0.78 | PLD1 (0.47) | PLD1OPRK1CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329451-B1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES (JP) | 2006-08-23 | — | — | EP | disclosed |
| US-6919349-B2 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES, INC. (JP) | 2005-07-19 | — | — | US | disclosed |
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES INC. (JP) | 2004-05-06 | — | — | US | disclosed |
| EP-1329451-A1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2003-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | VCAM1, ICAM1, SELL | PLD1 4061/4885OPRK1 1419/4885CTSB 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.