SCHEMBL5799233

SCHEMBL5799233

CN1CCCC(CO)C1.CN1CCCC(COc2ccc([N+](=O)[O-])cc2F)C1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.45
S1PR4 O95977 1/20 0.43
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
HRH3 Q9Y5N1 5/20 0.40
KDM1A O60341 1/20 0.39
MAPT P10636 2/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
EGFR P00533 2/20 0.39
FGFR1 P11362 2/20 0.39
FLT1 P17948 2/20 0.39
FLT4 P35916 2/20 0.39
KDR P35968 2/20 0.39
CHRNB2 P17787 1/20 0.38
CHRNA4 P43681 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
DRD4 P21917 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3203873 0.95 CYP19A1 (0.48) CYP19A1S1PR4CHRNB4CHRNA3HRH3
SCHEMBL8791874 0.83 DRD4 (0.52) CYP19A1CHRNB4CHRNA3MAPTALDH1A1
SCHEMBL19462043 0.83 DRD4 (0.52) CYP19A1CHRNB4CHRNA3MAPTALDH1A1
SCHEMBL13419646 0.82 S1PR4 (0.50) CYP19A1S1PR4CHRNB4CHRNA3HRH3
SCHEMBL22069747 0.81 CYP19A1 (0.59) CYP19A1S1PR4ALDH1A1
SCHEMBL13419616 0.80 SCN9A (0.59) CYP19A1S1PR4MAPTALDH1A1LMNA
SCHEMBL2551985 0.78 S1PR4 (0.54) CYP19A1S1PR4ALDH1A1
SCHEMBL13419606 0.77 CYP19A1 (0.44) CYP19A1S1PR4CHRNB4CHRNA3MAPT
SCHEMBL3190605 0.77 SIGMAR1 (0.61) CHRNB4CHRNA3HRH3ALDH1A1MAOA
SCHEMBL13419327 0.77 MAOA (0.46) HRH3KDM1AEGFRFGFR1FLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1682531-A2 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2006-07-26 EP disclosed
WO-2005042518-A2 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2005-05-12 WO disclosed