Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.33 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041495 | 0.79 | KDM4E (0.54) | GLO1MMP2ALOX15HTTKDM4E | |
| SCHEMBL5800090 | 0.71 | PIK3C3 (0.32) | KMT2AL3MBTL1 | |
| SCHEMBL10263801 | 0.70 | EP300 (0.41) | HTR1DHTR1BHTR1FGLO1EP300 | |
| SCHEMBL3243143 | 0.69 | METAP2 (0.57) | ALOX15KDM4ENPC1LMNATP53 | |
| SCHEMBL1973088 | 0.66 | DEGS1 (0.46) | PIK3CG | |
| SCHEMBL13348672 | 0.65 | ALDH1A1 (0.42) | HTTKDM4ENPC1LMNAALOX12 | |
| SCHEMBL13313432 | 0.65 | CCR1 (0.55) | HTTKDM4ENPC1LMNARAB9A | |
| SCHEMBL13313431 | 0.65 | KDM4E (0.61) | MMP2ALOX15CCNCCDK8KDM4E | |
| SCHEMBL13485905 | 0.64 | KDM4E (0.49) | GLO1ALOX15HTTKDM4ENPC1 | |
| SCHEMBL13485893 | 0.62 | KDM4E (0.48) | GLO1ALOX15HTTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496836-A4 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1496836-A2 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003077850-A2 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |