Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303799 | 1.00 | OPRM1 (0.56) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL3729279 | 0.88 | OPRM1 (0.54) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL3729276 | 0.88 | OPRM1 (0.54) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL304093 | 0.87 | OPRL1 (0.75) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL541284 | 0.87 | OPRL1 (0.75) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL14277129 | 0.83 | LMNA (0.69) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL753058 | 0.82 | LMNA (0.52) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL18526696 | 0.82 | LMNA (0.52) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL303920 | 0.82 | LMNA (0.63) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL2707046 | 0.82 | LMNA (0.63) | OPRM1OPRK1OPRL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417126-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011075439-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-23 | — | — | WO | disclosed |
| EP-2328865-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2011059887-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011059850-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |