Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305262 | 1.00 | OPRM1 (0.39) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL305263 | 1.00 | OPRM1 (0.39) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL304094 | 0.88 | OPRL1 (0.53) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL304095 | 0.88 | OPRL1 (0.53) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL571259 | 0.68 | OPRM1 (0.38) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL1316739 | 0.68 | GAA (0.38) | OPRK1CYP1A2CYP2C9CYP2C19MAPK1 | |
| SCHEMBL1316741 | 0.68 | GAA (0.38) | OPRK1CYP1A2CYP2C9CYP2C19MAPK1 | |
| SCHEMBL571260 | 0.68 | OPRM1 (0.38) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL303920 | 0.67 | LMNA (0.63) | OPRM1OPRK1OPRL1OPRD1CYP2D6 | |
| SCHEMBL2707046 | 0.67 | LMNA (0.63) | OPRM1OPRK1OPRL1OPRD1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417126-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011075439-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011059887-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011059850-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |