Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 16/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870014 | 0.89 | FAAH (0.40) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL3873335 | 0.85 | CMA1 (0.38) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL3870369 | 0.83 | CTSS (0.43) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL5519871 | 0.79 | FAAH (0.43) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL5520458 | 0.79 | FAAH (0.43) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL27663433 | 0.79 | CTSS (0.50) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL3877756 | 0.77 | CTSS (0.47) | CTSSCYP3A4CYP2C9CTSK | |
| SCHEMBL6248431 | 0.76 | CTSS (0.49) | CTSSCYP3A4CYP2C9CTSK | |
| SCHEMBL6629760 | 0.76 | FAAH (0.47) | CTSSCYP3A4CYP2C9FAAHCES1 | |
| SCHEMBL6629762 | 0.76 | FAAH (0.47) | CTSSCYP3A4CYP2C9FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | disclosed |