SCHEMBL5800660

SCHEMBL5800660

CCCOC(=O)[C@H](C)c1c(C)n(C(=O)c2ccc(F)c(F)c2)c2cc(F)c(O)c(F)c12

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 11/20 0.37
ALDH1A1 P00352 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
AKR1C3 P42330 1/20 0.32
AKR1C2 P52895 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5800661 1.00 PTGS2 (0.37) PTGS2ALDH1A1MEN1KMT2AAKR1C3
SCHEMBL5796756 0.94 PTGS2 (0.39) PTGS2ALDH1A1
SCHEMBL5796759 0.94 PTGS2 (0.39) PTGS2ALDH1A1
SCHEMBL5813216 0.93 ALDH1A1 (0.35) PTGS2ALDH1A1MEN1KMT2AAKR1C3
SCHEMBL5813215 0.93 ALDH1A1 (0.35) PTGS2ALDH1A1MEN1KMT2AAKR1C3
SCHEMBL5808086 0.93 PTGS2 (0.36) PTGS2AKR1C3AKR1C2
SCHEMBL5808087 0.93 PTGS2 (0.36) PTGS2AKR1C3AKR1C2
SCHEMBL5798596 0.93 PTGS2 (0.44) PTGS2AKR1C3AKR1C2
SCHEMBL5798592 0.93 PTGS2 (0.44) PTGS2AKR1C3AKR1C2
SCHEMBL5797881 0.91 PTGS2 (0.36) PTGS2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006050120-A2 SYNTHESIS OF COX-2 AND FAAH INHIBITORS MICROBIA, INC. (US) 2006-05-11 WO disclosed