Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554259 | 0.95 | PTGS2 (0.49) | PTGS2PTGS1AKR1C3AKR1C2HRH4 | |
| SCHEMBL5555236 | 0.92 | AKR1C3 (0.50) | PTGS2PTGS1AKR1C3AKR1C2HRH4 | |
| SCHEMBL5559617 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1AKR1C3AKR1C2HRH4 | |
| SCHEMBL6426790 | 0.91 | PTGS2 (0.56) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL6466545 | 0.91 | PTGS2 (0.47) | PTGS2PTGS1AKR1C3AKR1C2HRH4 | |
| SCHEMBL5559329 | 0.91 | PTGS2 (0.50) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL5558419 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3AKR1C2HRH4 | |
| SCHEMBL5554753 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1HRH4HDAC3HDAC1 | |
| SCHEMBL6424846 | 0.89 | PTGS2 (0.62) | PTGS2PTGS1AKR1C3AKR1C2HRH4 | |
| SCHEMBL5554544 | 0.89 | PTGS2 (0.47) | PTGS2PTGS1AKR1C3AKR1C2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050032747-A1 | COX-2 and FAAH inhibitors | POLYMER CONCEPTS TECHNOLOGIES PBY, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032747-A1 | COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGS2 | PTGS2 3/4885PTGS1 6/4885AKR1C3 585/4885 |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | PTGS2 4/4885PTGS1 7/4885AKR1C3 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.