Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802959 | 0.90 | KDM4E (0.45) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL11692389 | 0.84 | KDM4E (0.53) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL11701026 | 0.83 | MEN1 (0.45) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL18475969 | 0.83 | NOS2 (0.47) | MEN1KMT2AHTTCHRM1DRD2 | |
| SCHEMBL4164624 | 0.82 | KDM4E (0.47) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL3586530 | 0.81 | ALDH1A1 (0.51) | KDM4EMEN1NPC1MITFALDH1A1 | |
| Hydrochloric Acid SCHEMBL22797780 | 0.81 | NOS2 (0.46) | KDM4EMEN1KMT2AHTTCHRM1 | |
| SCHEMBL10660611 | 0.81 | KMT2A (0.46) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL11692158 | 0.81 | OPRM1 (0.51) | KDM4EMEN1NPC1MITFALDH1A1 | |
| SCHEMBL17046111 | 0.81 | TRPV1 (0.47) | KDM4EMEN1NPC1MITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-4734490-A | TEXTILE DYEING AND PRINTING | CIBA-GEIGY CORPORATION (US) | 1988-03-29 | — | — | US | disclosed |
| US-4063887-A | HYDROXYAMINE COMPOUND | CELANESE CORPORATION (US) | 1977-12-20 | — | — | US | disclosed |
| US-4041025-A | FOR HYDROPHOBIC FIBERS SUCH AS POLYESTERS, YELLOW TO BLUE-GREEN SHADES | BASF AKTIENGESELLSCHAFT (DT) | 1977-08-09 | — | — | US | disclosed |