Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515983 | 0.89 | CHEK2 (0.40) | CHEK2TRPV1ATMPRMT5PDE7B | |
| SCHEMBL5801498 | 0.83 | TRPV1 (0.41) | CHEK2TRPV1ATMAPPHTR1A | |
| SCHEMBL5773134 | 0.83 | ATM (0.39) | CHEK2TRPV1ATMPRMT5PDE7B | |
| SCHEMBL5769599 | 0.79 | ATM (0.38) | CHEK2TRPV1ATMPRMT5PDE7B | |
| SCHEMBL5479174 | 0.78 | ATM (0.39) | CHEK2TRPV1ATMAPPHTR1A | |
| SCHEMBL5774380 | 0.78 | ALDH1A1 (0.39) | CHEK2TRPV1PRMT5PDE7BALDH1A1 | |
| SCHEMBL8262110 | 0.76 | TRPV1 (0.40) | CHEK2TRPV1ATMAPPHTR1A | |
| SCHEMBL6174216 | 0.75 | ATM (0.46) | CHEK2TRPV1ATMAPPHTR1A | |
| SCHEMBL2915181 | 0.75 | ATM (0.46) | CHEK2TRPV1ATMAPPHTR1A | |
| SCHEMBL3126719 | 0.75 | ATM (0.46) | CHEK2TRPV1ATMAPPHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066899-A1 | NOVEL THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| EP-1674464-A1 | Novel thrombin inhibitors | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2006-06-28 | — | — | EP | disclosed |
| EP-1674464-A1 | Novel thrombin inhibitors | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2006-06-28 | — | — | EP | disclosed |