Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785750 | 0.92 | SIRT6 (0.47) | MAPTALDH1A1GAATP53SIRT6 | |
| SCHEMBL5784686 | 0.90 | MAPK11 (0.47) | MAPTALDH1A1SIRT6MAPK14MAPK11 | |
| SCHEMBL5784669 | 0.90 | MAPK11 (0.47) | MAPTALDH1A1SIRT6MAPK14MAPK11 | |
| SCHEMBL5805476 | 0.88 | MAPK14 (0.51) | MAPK14MAPK11 | |
| SCHEMBL1140179 | 0.88 | POLB (0.57) | MAPTHPGDMAPK1ALDH1A1TDP1 | |
| SCHEMBL5788418 | 0.88 | SIRT6 (0.55) | MAPTMAPK1ALDH1A1GAASIRT6 | |
| SCHEMBL1140045 | 0.87 | MAPK11 (0.48) | MAPTALDH1A1SIRT6MAPK14MAPK11 | |
| SCHEMBL1140167 | 0.87 | MEN1 (0.52) | MAPTALDH1A1SIRT6MAPK14MAPK11 | |
| SCHEMBL5789210 | 0.87 | MAPK11 (0.49) | MAPTALDH1A1SIRT6MAPK14MAPK11 | |
| SCHEMBL1139935 | 0.86 | MAPT (0.54) | MAPTMAPK1ALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682520-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042502-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-12 | — | — | WO | disclosed |