Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.45 |
| ▸ | MMP13 | P45452 | 9/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608781 | 0.78 | MMP2 (0.56) | MMP2MMP13ADAMTS4MMP14MMP9 | |
| SCHEMBL15714264 | 0.68 | SMN1; SMN2 (0.58) | KMT2AMEN1LMNA | |
| SCHEMBL13314483 | 0.62 | MMP13 (1.00) | MMP2MMP13ADAMTS4MMP14MMP9 | |
| SCHEMBL3607658 | 0.62 | MMP13 (1.00) | MMP2MMP13ADAMTS4MMP14MMP9 | |
| SCHEMBL13314502 | 0.61 | MMP2 (1.00) | MMP2MMP13ADAMTS4MMP14MMP9 | |
| SCHEMBL3607424 | 0.61 | MMP2 (1.00) | MMP2MMP13ADAMTS4MMP14MMP9 | |
| SCHEMBL28195528 | 0.60 | HIF1A (0.61) | KMT2AMEN1TP53 | |
| SCHEMBL2703745 | 0.60 | MMP2 (0.55) | MMP2MMP13ADAMTS4MMP14MMP9 | |
| SCHEMBL12325767 | 0.60 | ABCG2 (0.54) | KMT2AMEN1LMNATP53 | |
| SCHEMBL16396579 | 0.59 | ALDH1A1 (0.58) | KMT2AMEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | claimed |
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |