Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419527 | 0.93 | GPR119 (0.49) | NR1H2NR1H3GPR119ALDH1A1GAA | |
| SCHEMBL5802188 | 0.89 | NR1H2 (0.47) | NR1H2NR1H3GPR119ALDH1A1GAA | |
| SCHEMBL27113981 | 0.89 | SMN1; SMN2 (0.47) | NR1H2NR1H3GPR119ALDH1A1GAA | |
| SCHEMBL1884146 | 0.88 | CASP3 (0.48) | ALDH1A1GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL419123 | 0.88 | GPR119 (0.51) | GPR119ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18764600 | 0.87 | NR1H2 (0.50) | NR1H2NR1H3GPR119ALDH1A1GAA | |
| SCHEMBL15127746 | 0.86 | ALDH1A1 (0.46) | NR1H2NR1H3GPR119ALDH1A1GAA | |
| SCHEMBL28788513 | 0.84 | GPR119 (0.51) | GPR119GAASMN1; SMN2HPGDKDM4E | |
| SCHEMBL18764918 | 0.83 | NR1H2 (0.51) | NR1H2NR1H3GPR119ALDH1A1GAA | |
| SCHEMBL12003104 | 0.82 | NR1H2 (0.49) | NR1H2NR1H3GPR119ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |