Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14234001 | 1.00 | IDO1 (0.59) | IDO1PDPK1CA1CA2GPR84 | |
| SCHEMBL242245 | 0.89 | IDO1 (0.62) | IDO1GPR84FFAR1 | |
| SCHEMBL756933 | 0.83 | IDO1 (0.61) | IDO1PDPK1GPR84CYP11B2ACP3 | |
| SCHEMBL17310830 | 0.81 | IDO1 (0.59) | IDO1PDPK1GPR84CYP11B2 | |
| SCHEMBL376248 | 0.78 | IDO1 (0.70) | IDO1PDPK1GPR84CYP11B2 | |
| SCHEMBL17310949 | 0.77 | IDO1 (0.54) | IDO1PDPK1GPR84FFAR1 | |
| SCHEMBL6046104 | 0.76 | IDO1 (0.45) | IDO1PDPK1CA1CA2 | |
| SCHEMBL10469818 | 0.75 | MTNR1A (0.49) | — | |
| SCHEMBL447419 | 0.75 | IDO1 (0.66) | IDO1PDPK1CA1CA2GPR84 | |
| SCHEMBL21300294 | 0.75 | IDO1 (0.66) | IDO1PDPK1GPR84CYP11B2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 225 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758051-B1 | CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-11 | — | — | EP | claimed |
| CN-105565405-B | A kind of vertical Quick purifying device and its process for purifying water | 徐州工程学院 | 2018-01-19 | — | — | CN | claimed |
| EP-2758389-B1 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | claimed |
| US-9394282-B2 | Pyrazole carboxamides as Janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-19 | — | — | US | claimed |
| CN-105565405-A | Vertical type rapid water purifying device and water purifying method thereof | XUZHOU INST TECHNOLOGY | 2016-05-11 | — | — | CN | claimed |
| US-9328099-B2 | Cyanomethylpyrazole carboxamides as janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-05-03 | — | — | US | claimed |
| US-20140235641-A1 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | INTERVET INC. | 2014-08-21 | — | — | US | claimed |
| US-20140228348-A1 | CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME LLC | 2014-08-14 | — | — | US | claimed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | claimed |
| CN-101730694-A | Substituted deuterium enriched thiophenes for the treatment of hypertension | AUSPEX PHARMACEUTICALS INC | 2010-06-09 | — | — | CN | claimed |
| US-4166905-A | ANTIBIOTICS | BRISTOL-MYERS COMPANY (US) | 1979-09-04 | — | — | US | claimed |
| US-4166906-A | ANTIBIOTICS | BRISTOL-MYERS COMPANY (US) | 1979-09-04 | — | — | US | claimed |
| US-4143039-A | ANTIBACTERIAL 3-(5-TETRAZOLYL)PENAM COMPOUNDS | PFIZER INC. (US) | 1979-03-06 | — | — | US | claimed |
| US-4138486-A | BACTERICIDES | SHIONOGI & CO., LTD. (JP) | 1979-02-06 | — | — | US | claimed |
| US-4118566-A | Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1978-10-03 | — | — | US | claimed |
| US-4115385-A | PENICILLINS | PFIZER INC. (US) | 1978-09-19 | — | — | US | claimed |
| US-4113946-A | Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1978-09-12 | — | — | US | claimed |
| US-4112230-A | Δ2,3 -1,4 Morpholine-2-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1978-09-05 | — | — | US | claimed |
| US-4091210-A | Preparation of 3-alkyl-3-cephem-4-carboxylic acid compounds from dithio isopropenyl azetidine carboxylic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1978-05-23 | — | — | US | claimed |
| US-4081443-A | Penicillin oxides | SHIONOGI & CO., LTD. (JA) | 1978-03-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228348-A1 | CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | JAK1, JAK2, JAK3 | IDO1 375/4885PDPK1 445/4885CA1 1965/4885 |
| US-20140235641-A1 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | JAK1, JAK3, JAK2 | IDO1 239/4885PDPK1 288/4885CA1 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.