Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28099224 | 0.81 | KDM4E (0.53) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL28233 | 0.81 | KDM4E (0.53) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL10410895 | 0.79 | KDM4E (0.50) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL2487083 | 0.79 | RAB9A (0.56) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL6516869 | 0.79 | KDM4E (0.58) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL4386263 | 0.78 | KDM4E (0.72) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL1187034 | 0.77 | KDM4E (0.49) | KDM4ERAB9ANPC1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL7707460 | 0.77 | RAB9A (0.55) | KDM4ERAB9ANPC1MAPTLMNA | |
| SCHEMBL6222097 | 0.77 | LMNA (0.49) | KDM4ERAB9ANPC1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL27496748 | 0.76 | KDM4E (0.59) | KDM4ERAB9ANPC1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506185-B1 | COMPOUNDS AND THEIR USE AS INHIBITORS OF 5-HT | BIOVITRUM AB (SE) | 2006-05-24 | — | — | EP | claimed |