Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.91 |
| ▸ | LMNA | P02545 | 2/20 | 0.91 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | AKT1 | P31749 | 6/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA3 | P07451 | 1/20 | 0.62 |
| ▸ | CA6 | P23280 | 1/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.62 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.62 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethizole SCHEMBL26453 | 0.96 | ALDH1A1 (1.00) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL1566142 | 0.94 | ALDH1A1 (0.97) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL28693374 | 0.93 | ALDH1A1 (0.94) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL9292378 | 0.91 | ALDH1A1 (0.91) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL9018487 | 0.91 | ALDH1A1 (0.91) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL17261454 | 0.90 | ALDH1A1 (0.89) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethazine SCHEMBL28122262 | 0.84 | ALDH1A1 (0.78) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL11699385 | 0.84 | ALDH1A1 (0.78) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL11893082 | 0.83 | ALDH1A1 (0.77) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL3844013 | 0.82 | ALDH1A1 (0.74) | ALDH1A1LMNAPKMHPGDAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417241-A2 | PROCESS AND APPARATUS FOR REMOVAL OF CONTAMINATING MATERIAL FROM SUBSTRATES | Sunsonix (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118206-A2 | PROCESS AND APPARATUS FOR REMOVAL OF CONTAMINATING MATERIAL FROM SUBSTRATES | SUNSONIX (US) | 2010-10-14 | — | — | WO | disclosed |