Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24787166 | 0.79 | HTR2C (0.47) | HTR2CCHEK1AURKADAPK3PRKD3 | |
| SCHEMBL1750073 | 0.76 | NPC1 (0.42) | HTR2CALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14118036 | 0.73 | XIAP (0.40) | CYP11B1CYP11B2XIAPBIRC2 | |
| SCHEMBL17318021 | 0.73 | KDR (0.59) | CYP11B1CYP11B2HTR2CCHEK1AURKA | |
| SCHEMBL27978057 | 0.70 | XIAP (0.38) | CYP11B1CYP11B2XIAPBIRC2 | |
| SCHEMBL6615342 | 0.69 | ADK (0.42) | HTR2CCSNK1A1GSK3BALDH1A1NPC1 | |
| SCHEMBL11281012 | 0.69 | SMN1; SMN2 (0.50) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL11884599 | 0.68 | MAOA (0.41) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL26671809 | 0.68 | XIAP (0.44) | CYP11B1CYP11B2METXIAPBIRC2 | |
| SCHEMBL3835689 | 0.67 | CYP1A2 (0.47) | CYP11B1CYP11B2KDRGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |