Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804166 | 0.79 | CYP11B1 (0.42) | HTR2CTYRO3NTRK2CLK4DYRK1B | |
| SCHEMBL17318021 | 0.76 | KDR (0.59) | HTR2CTNKS2TYRO3NTRK2CLK4 | |
| SCHEMBL17396409 | 0.73 | TYRO3 (0.35) | TYRO3DYRK1BNFKB1NFKB2RELA | |
| SCHEMBL1253734 | 0.67 | CA12 (0.38) | TNKS2ABL1KDRGSK3BMAP2K1 | |
| SCHEMBL1750073 | 0.67 | NPC1 (0.42) | HTR2CTNKS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14940686 | 0.67 | HTR2C (0.39) | HTR2CTNKS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17811730 | 0.67 | PDE3B (0.56) | TYRO3NTRK2CLK4DYRK1BCHEK1 | |
| SCHEMBL17396612 | 0.66 | MKNK2 (0.35) | — | |
| SCHEMBL17811701 | 0.66 | CYP11B1 (0.52) | TYRO3NTRK2CLK4DYRK1BCHEK1 | |
| SCHEMBL11884599 | 0.65 | MAOA (0.41) | TYRO3NTRK2CLK4DYRK1BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022257875-A1 | PYRIMIDINE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海日馨医药科技股份有限公司 | 2022-12-15 | — | — | WO | disclosed |