Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804213 | 1.00 | MAPT (0.51) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6924873 | 0.76 | MAPT (0.56) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30523171 | 0.76 | MEN1 (0.74) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1071505 | 0.76 | KIF11 (0.55) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12408499 | 0.76 | KIF11 (0.55) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30440640 | 0.76 | KIF11 (0.55) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4024926 | 0.76 | MEN1 (0.74) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6137514 | 0.75 | TTR (0.46) | MAPTKDM4EALDH1A1SMN1; SMN2TTR | |
| SCHEMBL6070704 | 0.75 | TTR (0.46) | MAPTKDM4EALDH1A1SMN1; SMN2TTR | |
| SCHEMBL16595932 | 0.72 | TTR (0.58) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006101456-A1 | BICYCLIC HETEROCYCLES HYDROXAMATE COMPOUNDS USEFUL AS HISTONE DEACETYLASE (HDAC) INHIBITORS | S*BIO PTE LTD (SG) | 2006-09-28 | — | — | WO | disclosed |