Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744168 | 0.76 | OPRM1 (0.45) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL22634143 | 0.74 | OPRM1 (0.53) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL3210914 | 0.72 | CYP1A2 (0.51) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL28171354 | 0.72 | OPRM1 (0.41) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL7887937 | 0.72 | SMN1; SMN2 (0.52) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL5515087 | 0.72 | NPFFR1 (0.52) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL654160 | 0.69 | KDM4E (0.51) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL9749001 | 0.68 | NPFFR1 (0.46) | OPRM1CYP2D6CYP1A2NPFFR1NPFFR2 | |
| SCHEMBL782996 | 0.68 | CYP1A2 (0.51) | CYP2D6CYP1A2NPFFR1NPFFR2TSHR | |
| Hydrochloric Acid SCHEMBL1392623 | 0.68 | HTR6 (0.41) | OPRM1ALDH1A1KMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699761-A1 | CB1 MODULATOR COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005066126-A1 | CB1 MODULATOR COMPOUNDS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |