Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MC3R | P41968 | 11/20 | 0.52 |
| ▸ | MC4R | P32245 | 9/20 | 0.52 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.52 |
| ▸ | MC5R | P33032 | 11/20 | 0.52 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808553 | 0.87 | CDK4 (0.53) | CDK4CCND1 | |
| SCHEMBL5807585 | 0.81 | HDAC1 (0.48) | KMT2ACDK4TRPM8TRPV1TAAR1 | |
| SCHEMBL5804435 | 0.79 | MC5R (0.49) | KMT2AMEN1MC3RMC4RMC5R | |
| SCHEMBL12464095 | 0.76 | NLN (0.66) | KMT2AMEN1MC3RMC4RNLN | |
| SCHEMBL5807581 | 0.75 | MAPT (0.64) | KMT2AMEN1 | |
| SCHEMBL5807408 | 0.75 | SIRT1 (0.67) | KMT2AMEN1CDK4TRPV1ACHE | |
| SCHEMBL11066319 | 0.74 | MC4R (0.60) | KMT2AMEN1MC3RMC4RNLN | |
| SCHEMBL11068554 | 0.74 | MC3R (0.74) | KMT2AMEN1MC3RMC4RMC5R | |
| SCHEMBL18229448 | 0.74 | MEN1 (0.85) | KMT2AMEN1MC3RMC4RMC5R | |
| SCHEMBL30777136 | 0.74 | MEN1 (0.85) | KMT2AMEN1MC3RMC4RMC5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |