Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580548 | 0.85 | AURKA (0.51) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581552 | 0.84 | AURKA (0.52) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581677 | 0.82 | AURKA (0.55) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581165 | 0.80 | AURKA (0.69) | AURKAAURKBTPX2 | |
| SCHEMBL580535 | 0.77 | AURKA (0.59) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581019 | 0.76 | AURKA (0.58) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL15809924 | 0.75 | AURKA (0.52) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL580459 | 0.73 | ENPP3 (0.51) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL581534 | 0.73 | AURKA (0.59) | AURKAAURKBTPX2MAPTLMNA | |
| SCHEMBL17366294 | 0.72 | AURKA (0.64) | AURKAAURKBTPX2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |