Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724434 | 0.80 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL724182 | 0.79 | ALDH1A1 (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8963515 | 0.76 | NISCH (0.42) | SMN1; SMN2ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL27601952 | 0.74 | NR4A2 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL15180532 | 0.74 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL1078329 | 0.74 | CHEK2 (0.48) | RAB9AALDH1A1 | |
| SCHEMBL26373225 | 0.72 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL21096059 | 0.72 | SMN1; SMN2 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10192214 | 0.71 | RAB9A (0.81) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL3223877 | 0.71 | RAB9A (0.81) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |