SCHEMBL5805293

SCHEMBL5805293

Cc1ccc(SC[C]=O)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
MAPT P10636 3/20 0.43
RAB9A P51151 3/20 0.41
NPC1 O15118 2/20 0.41
HPGD P15428 6/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
USP2 O75604 1/20 0.40
GAA P10253 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KDM4E B2RXH2 1/20 0.39
POLB P06746 1/20 0.39
THRB P10828 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MAPK1 P28482 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
CRBN Q96SW2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3238761 0.77 MAOA (0.43) ALDH1A1MAPTRAB9ANPC1MEN1
SCHEMBL10954827 0.77 CYP3A4 (0.44) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL7699314 0.77 CA2 (0.48) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL5178079 0.77 CA12 (0.53) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL5537420 0.77 SMN1; SMN2 (0.48) ALDH1A1MAPTRAB9ANPC1MEN1
SCHEMBL2320892 0.77 MAOA (0.43) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL10395941 0.77 HPGD (0.47) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL16439993 0.77 ALDH1A1 (0.53) ALDH1A1MAPTRAB9ANPC1SMN1; SMN2
SCHEMBL10955848 0.77 GRM2 (0.37) ALDH1A1MAPTRAB9ANPC1HPGD
SCHEMBL302722 0.76 ALDH1A1 (0.52) ALDH1A1MAPTRAB9ANPC1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006093518-A2 THIENYL COMPOUNDS FOR TREATING VIRUS-RELATED CONDITIONS APATH, LLC (US) 2006-09-08 WO disclosed
US-4992544-A Intermediates for b-lactam antibiotics and b-lactamase inhibitor UNIVERSITY OF NOTRE DAME DU LAC (US) 1991-02-12 US disclosed
US-4044000-A Substituted β-lactam antibiotics ELI LILLY AND COMPANY (US) 1977-08-23 US disclosed
US-3994885-A WITH ALKALI METAL ALKOXIDE, HALOGENATION ELI LILLY AND COMPANY (US) 1976-11-30 US disclosed