Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580224 | 0.86 | CYP2C9 (0.55) | OPRM1OPRD1OPRK1RECQLALDH1A1 | |
| SCHEMBL580054 | 0.78 | OPRM1 (0.55) | OPRM1OPRD1OPRK1RECQLALDH1A1 | |
| SCHEMBL579606 | 0.77 | OPRM1 (0.65) | OPRM1OPRD1OPRK1RECQLALDH1A1 | |
| SCHEMBL580457 | 0.76 | OPRM1 (0.58) | OPRM1OPRD1OPRK1RECQLALDH1A1 | |
| SCHEMBL580592 | 0.76 | OPRM1 (0.56) | OPRM1OPRD1OPRK1RECQLMEN1 | |
| SCHEMBL5718110 | 0.76 | ALDH1A1 (0.62) | ALDH1A1HPGDKMT2AEPHX2MAPT | |
| SCHEMBL579469 | 0.76 | OPRM1 (0.67) | OPRM1OPRD1OPRK1RECQLHPGD | |
| SCHEMBL579849 | 0.76 | OPRM1 (0.53) | OPRM1OPRD1OPRK1RECQLALDH1A1 | |
| SCHEMBL580225 | 0.75 | SMN1; SMN2 (0.71) | OPRM1OPRD1OPRK1RECQLALDH1A1 | |
| SCHEMBL580074 | 0.74 | OPRM1 (0.51) | OPRM1OPRD1OPRK1RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735268-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-02-15 | — | — | EP | claimed |