Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822134 | 0.90 | ROCK2 (0.32) | CXCR4ROCK2 | |
| SCHEMBL5811828 | 0.90 | ROCK2 (0.32) | CXCR4ROCK2 | |
| SCHEMBL5606422 | 0.87 | POLB (0.44) | POLBTP53MAPTLMNARXFP1 | |
| SCHEMBL5606187 | 0.87 | POLB (0.44) | POLBTP53MAPTLMNARXFP1 | |
| SCHEMBL1737749 | 0.87 | POLB (0.44) | POLBTP53MAPTLMNARXFP1 | |
| SCHEMBL5180557 | 0.87 | ELANE (0.38) | POLBTP53MAPTLMNARXFP1 | |
| SCHEMBL5806927 | 0.87 | ROCK2 (0.34) | EGLN1CXCR4ROCK2GPR119 | |
| SCHEMBL5807940 | 0.85 | EGLN1 (0.33) | EGLN1CXCR4ROCK2 | |
| SCHEMBL5819231 | 0.85 | ADAM17 (0.36) | ROCK2P2RX3 | |
| SCHEMBL5811632 | 0.84 | EGLN1 (0.33) | EGLN1CXCR4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | disclosed |