Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 6/20 | 0.38 |
| ▸ | TK1 | P04183 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466112 | 0.82 | CHRNB2 (0.46) | KLK7KDM4EPKMUSP30 | |
| SCHEMBL17169858 | 0.81 | KLK7 (0.50) | KLK7STSKLK5PRSS1PRSS2 | |
| SCHEMBL29997836 | 0.81 | KLK7 (0.50) | KLK7STSKLK5PRSS1PRSS2 | |
| SCHEMBL30466123 | 0.81 | CHRNB2 (0.46) | KLK7KDM4EPKMUSP30 | |
| SCHEMBL5806582 | 0.81 | GPR119 (0.39) | KLK7GPR119STSKLK5KDM4E | |
| SCHEMBL5806586 | 0.81 | GPR119 (0.39) | KLK7GPR119STSKLK5KDM4E | |
| SCHEMBL7067181 | 0.79 | SMYD2 (0.39) | KLK7GPR119STSKLK5KDM4E | |
| SCHEMBL7518554 | 0.79 | SMYD2 (0.39) | KLK7GPR119STSKLK5KDM4E | |
| SCHEMBL30683282 | 0.79 | SMYD2 (0.39) | KLK7GPR119STSKLK5KDM4E | |
| SCHEMBL598389 | 0.78 | KLK7 (0.45) | KLK7STSKLK5PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105386-A1 | CDK2 INHIBITORS | GENENTECH, INC. (US) | 2006-10-05 | — | — | WO | disclosed |