Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | KLK7 | P49862 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | WNT3 | P56703 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806582 | 1.00 | GPR119 (0.39) | GPR119KLK7KDM4EPKMWNT3 | |
| SCHEMBL7273493 | 0.83 | SMN1; SMN2 (0.44) | CYP2C19 | |
| SCHEMBL8863308 | 0.83 | SMN1; SMN2 (0.44) | CYP2C19 | |
| SCHEMBL25694076 | 0.81 | CHRNB2 (0.50) | GPR119KLK7KDM4EPKMHIF1A | |
| SCHEMBL25694074 | 0.81 | CHRNB2 (0.50) | GPR119KLK7KDM4EPKMHIF1A | |
| SCHEMBL19419776 | 0.81 | KLK7 (0.51) | GPR119KLK7STSKLK5PRSS1 | |
| SCHEMBL3728443 | 0.81 | KLK7 (0.51) | GPR119KLK7STSKLK5PRSS1 | |
| SCHEMBL15383781 | 0.81 | KLK7 (0.51) | GPR119KLK7STSKLK5PRSS1 | |
| SCHEMBL5807219 | 0.81 | KLK7 (0.38) | GPR119KLK7KDM4EPKMSLC6A1 | |
| SCHEMBL1150304 | 0.79 | SMYD2 (0.38) | GPR119KLK7KDM4EPKMWNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105386-A1 | CDK2 INHIBITORS | GENENTECH, INC. (US) | 2006-10-05 | — | — | WO | disclosed |