Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.50 |
| ▸ | PTGES | O14684 | 6/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807982 | 0.93 | PTGES (0.56) | EGFRERBB2PTGESALOX5GAA | |
| SCHEMBL5808608 | 0.91 | EGFR (0.53) | EGFRERBB2PTGESALOX5FLT1 | |
| SCHEMBL5804797 | 0.88 | HTR6 (0.52) | EGFRERBB2PTGESALOX5LMNA | |
| SCHEMBL5807053 | 0.88 | PTGES (0.52) | EGFRERBB2PTGESALOX5LMNA | |
| SCHEMBL5804879 | 0.87 | PTGES (0.51) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5807526 | 0.86 | EGFR (0.58) | EGFRERBB2PTGESALOX5LMNA | |
| SCHEMBL5805211 | 0.85 | EGFR (0.43) | EGFRERBB2PTGESALOX5TRPV1 | |
| SCHEMBL5806852 | 0.84 | ALDH1A1 (0.50) | EGFRERBB2PTGESALOX5GAA | |
| SCHEMBL5808774 | 0.84 | ALDH1A1 (0.59) | EGFRERBB2PTGESALOX5LMNA | |
| SCHEMBL5808959 | 0.83 | POLB (0.51) | EGFRERBB2PTGESALOX5FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | claimed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |