SCHEMBL58080

SCHEMBL58080

O=[N+]([O-])c1cc(F)c(F)cc1F

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.58
ATM Q13315 1/20 0.58
ALDH1A1 P00352 5/20 0.56
HIF1A Q16665 2/20 0.56
VCAM1 P19320 1/20 0.52
ESPL1 Q14674 1/20 0.50
MAPT P10636 6/20 0.42
PKM P14618 2/20 0.42
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
RAB9A P51151 1/20 0.41
MAPK1 P28482 2/20 0.41
KDM4E B2RXH2 2/20 0.40
RECQL P46063 2/20 0.40
CYP19A1 P11511 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29403879 1.00 TDP1 (0.58) TDP1ATMALDH1A1HIF1AVCAM1
Benzene SCHEMBL28328708 0.95 TDP1 (0.54) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL4670199 0.95 TDP1 (0.62) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL45486 0.92 TDP1 (0.60) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL3756498 0.89 TDP1 (0.56) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL30257990 0.89 TDP1 (0.56) TDP1ATMALDH1A1HIF1AVCAM1
Acetic Acid SCHEMBL28120227 0.87 ATM (0.47) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL17980429 0.81 TDP1 (0.50) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL2413345 0.81 TDP1 (0.50) TDP1ATMALDH1A1HIF1AVCAM1
SCHEMBL21810725 0.81 TDP1 (0.50) TDP1ATMALDH1A1HIF1AVCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 763 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116891413-A Method for continuously preparing 2,4, 5-trifluoroaniline 山东东岳高分子材料有限公司 2023-10-17 CN claimed
CN-110498730-B Synthetic method of 1,2, 4-trifluorobenzene 浙江吉泰新材料股份有限公司 2021-12-03 CN claimed
CN-109400459-B Preparation method of 2,4, 5-trifluoro-phenylacetic acid 浙江工业大学上虞研究院有限公司 2021-07-23 CN claimed
CN-110498730-A A kind of synthetic method of 1,2,4- trifluoro-benzene ZHEJIANG LINJIANG CHEMICAL CO LTD 2019-11-26 CN claimed
CN-108273504-B A kind of nitrogen-doped graphene load ferrum-based catalyst and its preparation method and application 浙江大学 2019-10-18 CN claimed
CN-109400459-A The preparation method of 2,4,5- trifluoro benzene acetic acid 浙江工业大学上虞研究院有限公司 2019-03-01 CN claimed
CN-108273504-A A kind of nitrogen-doped graphene load ferrum-based catalyst and its preparation method and application 浙江大学 2018-07-13 CN claimed
CN-105111985-B Conductive silver glue for assembling LED 苏州晶雷光电照明科技有限公司 2017-08-25 CN claimed
CN-105111985-A Conductive silver adhesive for assembling LED SUZHOU CRYSTAL RAY PHOTOELECTRIC LIGHTING TECHNOLO 2015-12-02 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
CN-103012111-A Preparation method 2,4,5-trifluorophenylacetic acid UNIV QUZHOU 2013-04-03 CN claimed
JP-1026538-A None JP disclosed
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
EP-3743068-B1 COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS EXELIXIS INC (US) 2026-04-29 EP disclosed
US-20260102406-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA INC (US) 2026-04-16 US disclosed
JP-S6426538-A PRODUCTION OF 2,4,5-TRIFLUORONITROBENZENE SEIMI CHEM KK 1989-01-27 JP disclosed
EP-0295233-A2 Substituted 3-(4-nitrophenoxy)pyrazoles and their use as herbicides Monsanto Company (US) 1988-12-14 EP disclosed
US-4172831-A CENTRAL NERVOUS SYSTEM LILLY INDUSTRIES LIMITED (GB) 1979-10-30 US disclosed
US-4115574-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed
US-4115568-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF STAT6, NCOR2, NCOR1 TDP1 4803/4885ATM 3145/4885ALDH1A1 2085/4885
US-20260102406-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY BRAF, TTK, MAP4K2 TDP1 1468/4885ATM 102/4885ALDH1A1 3080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.