Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.73 |
| ▸ | CNR2 | P34972 | 5/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952544 | 0.85 | PLA2G2A (0.82) | PLA2G2APTGS1PLA2G1BPTGS2MEN1 | |
| SCHEMBL7952825 | 0.84 | PLA2G2A (1.00) | PLA2G2APTGS2 | |
| SCHEMBL7968767 | 0.83 | PLA2G2A (0.78) | PLA2G2ACNR2PLA2G1BPTGS2MEN1 | |
| SCHEMBL3889556 | 0.75 | LMNA (0.72) | PLA2G2APTGS1PLA2G1BPTGS2MEN1 | |
| SCHEMBL602385 | 0.74 | PLA2G2A (0.54) | PLA2G2ACNR2CNR1 | |
| SCHEMBL5817145 | 0.74 | PLA2G2A (0.63) | PLA2G2APTGS1PTGS2 | |
| SCHEMBL13776405 | 0.71 | PLA2G2A (0.55) | PLA2G2APLA2G1BPTGS2MEN1RGS12 | |
| SCHEMBL602524 | 0.70 | CNR2 (0.56) | PLA2G2ACNR2CNR1ALDH1A1 | |
| SCHEMBL600940 | 0.69 | PLA2G2A (0.57) | PLA2G2ACNR2CNR1MAPT | |
| SCHEMBL11863143 | 0.68 | PLA2G2A (0.51) | PLA2G2ACNR2CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006099416-A1 | 2-METHYL INDOLE CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2006-09-21 | — | — | WO | claimed |