Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 8/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808754 | 1.00 | LOX (0.40) | LOXLOXL2LMNAGAABCAT1 | |
| SCHEMBL5804502 | 0.77 | LMNA (0.61) | LMNAGAABCAT1ALDH1A1TAAR1 | |
| SCHEMBL5804505 | 0.77 | LMNA (0.61) | LMNAGAABCAT1ALDH1A1TAAR1 | |
| SCHEMBL8260574 | 0.75 | LMNA (0.43) | LMNAGAABCAT1ALDH1A1 | |
| SCHEMBL5804781 | 0.72 | CA2 (0.54) | LOXLOXL2MAOA | |
| SCHEMBL5808038 | 0.72 | LMNA (0.40) | LMNAGAABCAT1 | |
| SCHEMBL5808036 | 0.72 | LMNA (0.40) | LMNAGAABCAT1 | |
| SCHEMBL2650730 | 0.71 | LMNA (0.47) | LMNAGAAALDH1A1TSHR | |
| SCHEMBL2653000 | 0.71 | LMNA (0.47) | LMNAGAAALDH1A1TSHR | |
| SCHEMBL4972178 | 0.68 | LMNA (0.70) | LMNAGAABCAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |