SCHEMBL5808694

SCHEMBL5808694

Cc1ccc(-n2nc(C(=O)NC34CC5CC(C)(CC(C)(C5)C3)C4)c3c2CCCC3)cc1Cl

nearest known ligand 0.68

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 5/20 0.68
CNR1 P21554 4/20 0.68
UGCG Q16739 4/20 0.52
EPHX2 P34913 6/20 0.45
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38
KMT2A Q03164 1/20 0.38
STAT1 P42224 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5822464 0.89 CNR2 (0.85) CNR2CNR1UGCG
SCHEMBL5806769 0.79 CNR2 (0.96) CNR2CNR1UGCG
SCHEMBL5809664 0.79 CNR2 (0.56) CNR2CNR1EPHX2GAA
SCHEMBL5823767 0.75 CNR2 (0.75) CNR2CNR1UGCGEPHX2
SCHEMBL5807932 0.74 UGCG (0.53) CNR2CNR1UGCGMEN1GAA
SCHEMBL5811776 0.73 CNR2 (0.75) CNR2CNR1EPHX2
SCHEMBL5795556 0.73 CNR2 (0.72) CNR2CNR1
SCHEMBL5795272 0.71 CNR2 (0.69) CNR2CNR1
SCHEMBL5808194 0.71 LMNA (0.54) CNR2CNR1UGCGMEN1KMT2A
SCHEMBL14003108 0.71 CNR2 (0.71) CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006030124-A1 CONDENSED PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME SANOFI-AVENTIS (FR) 2006-03-23 WO disclosed