Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 5/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5791860 | 0.80 | CTSS (0.36) | CTSSLNPEPPAK4CTSK | |
| SCHEMBL5806357 | 0.77 | FGFR4 (0.37) | CTSSPAK4CTSKOPRM1OPRL1 | |
| Trifluoroacetic Acid SCHEMBL5792007 | 0.75 | MAPT (0.37) | HRH4HRH3CTSSLNPEPCTSK | |
| Trifluoroacetic Acid SCHEMBL5791564 | 0.70 | CTSK (0.35) | HRH4HRH3LNPEPCTSKFGFR4 | |
| SCHEMBL8270020 | 0.69 | CTSK (0.35) | CTSSCTSKFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5791713 | 0.69 | CTSK (0.37) | HRH4HRH3CTSSCTSKFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5791710 | 0.67 | CTSK (0.38) | HRH4HRH3CTSSCTSKFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5794362 | 0.67 | CTSK (0.35) | CTSSPAK4CTSKFGFR4 | |
| SCHEMBL8270023 | 0.66 | TSHR (0.36) | CTSSCTSKFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5791900 | 0.65 | CTSK (0.44) | CTSSLNPEPCTSKFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |