Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.73 |
| ▸ | MGLL | Q99685 | 1/20 | 0.73 |
| ▸ | BCHE | P06276 | 7/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576912 | 0.98 | FAAH (0.76) | FAAHMGLLBCHEACHEMEN1 | |
| SCHEMBL27544341 | 0.93 | BCHE (0.66) | FAAHMGLLBCHEACHEMEN1 | |
| SCHEMBL25497646 | 0.89 | FAAH (0.60) | FAAHMGLLBCHEACHEMEN1 | |
| SCHEMBL12166742 | 0.89 | FAAH (0.77) | FAAHMGLLBCHEACHEMEN1 | |
| SCHEMBL10596238 | 0.86 | SMN1; SMN2 (0.69) | FAAHMGLLBCHEACHEMAOB | |
| SCHEMBL29633028 | 0.85 | MGLL (1.00) | FAAHMGLLMEN1CYP1A2CYP3A4 | |
| SCHEMBL27858010 | 0.85 | BCHE (0.76) | FAAHMGLLBCHEACHEMAOB | |
| SCHEMBL4274165 | 0.85 | MGLL (1.00) | FAAHMGLLMEN1CYP1A2CYP3A4 | |
| SCHEMBL27347819 | 0.85 | CHRM3 (0.66) | FAAHMGLLBCHEACHEMAOB | |
| SCHEMBL12166663 | 0.83 | FAAH (0.58) | FAAHMGLLBCHEMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053742-A | New tricyclic compound | ABBVIE 公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108774237-A | New tricyclic compound | ABBVIE 公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-104370909-B | Tricyclic compound | ABBVIE 公司 | 2018-09-11 | — | — | CN | disclosed |
| CN-103288793-A | Phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LTD | 2013-09-11 | — | — | CN | disclosed |
| CN-1585633-B | Phenylethanolamine derivatives for the treatment of respiratory diseases | GLAXO GROUP LTD | 2010-10-27 | — | — | CN | disclosed |
| CN-101701006-A | Phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LTD | 2010-05-05 | — | — | CN | disclosed |
| WO-2006130426-A2 | MODULATORS OF CCR-5 ACTIVITY | KEMIA, INC. (US) | 2006-12-07 | — | — | WO | disclosed |
| CN-1585633-A | Phenylethanolamine derivatives for the treatment of respiratory diseases | GLAXO GROUP LTD (GB) | 2005-02-23 | — | — | CN | disclosed |