Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK1 | P23458 | 4/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18950565 | 0.90 | HSD17B10 (0.70) | FGFR1HSD17B10ALDH1A1THRBSIRT2 | |
| SCHEMBL12089843 | 0.84 | FGFR1 (0.58) | FGFR1HSD17B10KMT2AALDH1A1THRB | |
| SCHEMBL23346451 | 0.82 | KMT2A (0.54) | FGFR1HSD17B10JAK2JAK1TYK2 | |
| SCHEMBL6445182 | 0.81 | HSD17B10 (0.59) | FGFR1HSD17B10JAK2JAK1TYK2 | |
| SCHEMBL2030743 | 0.81 | SIRT2 (0.71) | HSD17B10KMT2AALDH1A1SIRT2SIRT1 | |
| SCHEMBL8551152 | 0.79 | GFER (0.53) | FGFR1HSD17B10JAK2JAK1TYK2 | |
| SCHEMBL8551161 | 0.79 | GFER (0.53) | FGFR1HSD17B10JAK2JAK1TYK2 | |
| SCHEMBL6229878 | 0.79 | ALDH1A1 (0.71) | FGFR1HSD17B10KMT2AALDH1A1MEN1 | |
| SCHEMBL2309144 | 0.78 | MAPK1 (0.61) | KMT2AALDH1A1MEN1USP2TSHR | |
| SCHEMBL24175829 | 0.77 | KMT2A (0.52) | FGFR1HSD17B10JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664021-A1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021531-A1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |