Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 7/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809821 | 0.90 | EGLN1 (0.40) | EGLN1HRH3PDE9ADHFRGRM2 | |
| SCHEMBL5807977 | 0.88 | EGLN1 (0.41) | EGLN1HRH3DHFR | |
| SCHEMBL5822117 | 0.86 | EGLN1 (0.40) | EGLN1HRH3PDE9AHTR1ADHFR | |
| SCHEMBL5811720 | 0.86 | HRH3 (0.39) | EGLN1HRH3PDE9ADHFR | |
| SCHEMBL5809686 | 0.84 | EGLN1 (0.39) | EGLN1HRH3DHFRGRM2 | |
| SCHEMBL5811721 | 0.83 | HRH3 (0.42) | HRH3 | |
| SCHEMBL5214300 | 0.77 | HRH3 (0.37) | EGLN1HTR2AHRH3PDE9A | |
| SCHEMBL5812938 | 0.75 | EGLN1 (0.36) | EGLN1HRH3DHFRGRM2 | |
| SCHEMBL5166374 | 0.75 | ELANE (0.38) | EGLN1HRH3 | |
| SCHEMBL5810004 | 0.75 | EGLN1 (0.38) | EGLN1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | disclosed |