Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809821 | 0.95 | EGLN1 (0.40) | EGLN1MEN1POLBKMT2ADHFR | |
| SCHEMBL5812938 | 0.88 | EGLN1 (0.36) | EGLN1MEN1POLBKMT2ADHFR | |
| SCHEMBL5210531 | 0.87 | HRH3 (0.35) | EGLN1HRH3ROCK2PARP14 | |
| SCHEMBL5807977 | 0.86 | EGLN1 (0.41) | EGLN1DHFRHRH3USP2ALDH1A1 | |
| SCHEMBL5165411 | 0.85 | ROCK2 (0.38) | EGLN1HRH3ROCK2 | |
| SCHEMBL5822117 | 0.85 | EGLN1 (0.40) | EGLN1MEN1KMT2ADHFRHRH3 | |
| SCHEMBL5811720 | 0.84 | HRH3 (0.39) | EGLN1DHFRHRH3 | |
| SCHEMBL5810019 | 0.84 | EGLN1 (0.38) | EGLN1DHFRHRH3GRM2 | |
| SCHEMBL5808251 | 0.83 | EGLN1 (0.36) | EGLN1ROCK2 | |
| SCHEMBL5214300 | 0.82 | HRH3 (0.37) | EGLN1MEN1POLBKMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | disclosed |