Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515983 | 0.86 | CHEK2 (0.40) | ATMCHEK2PRMT5PDE8BPDE7B | |
| SCHEMBL5769599 | 0.86 | ATM (0.38) | ATMCHEK2GRM5PRMT5PDE8B | |
| SCHEMBL5769284 | 0.83 | CHEK2 (0.40) | ATMCHEK2PRMT5PDE8BPDE7B | |
| SCHEMBL5802463 | 0.82 | GRM5 (0.37) | ATMCHEK2GRM5PRMT5PDE7B | |
| SCHEMBL5769605 | 0.78 | TRPV1 (0.37) | ATMCHEK2PRMT5PDE8BPDE7B | |
| SCHEMBL5810771 | 0.76 | PDE8B (0.35) | ATMCHEK2PRMT5PDE8BPDE7B | |
| SCHEMBL5774380 | 0.75 | ALDH1A1 (0.39) | CHEK2GRM5PRMT5PDE7BTRPV1 | |
| SCHEMBL5479621 | 0.74 | ATM (0.39) | ATMCHEK2PRMT5PDE8BTRPV1 | |
| SCHEMBL5481717 | 0.73 | ATM (0.39) | ATMCHEK2PRMT5PDE8BTRPV1 | |
| SCHEMBL24739379 | 0.72 | ATM (0.48) | ATMCHEK2PDE8BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066899-A1 | NOVEL THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| EP-1674464-A1 | Novel thrombin inhibitors | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2006-06-28 | — | — | EP | disclosed |
| EP-1674464-A1 | Novel thrombin inhibitors | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2006-06-28 | — | — | EP | disclosed |