Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502850 | 0.90 | MEN1 (0.59) | PDE4BPDE4DPDE10AKMT2AMEN1 | |
| SCHEMBL7507341 | 0.77 | PDE10A (0.48) | PDE4BPDE10AADORA2AADORA1ALDH1A1 | |
| SCHEMBL15700620 | 0.76 | PDE4B (1.00) | PDE4BPDE4DKMT2AMEN1RXRA | |
| SCHEMBL19357666 | 0.71 | PDE10A (0.48) | PDE4BPDE10AKMT2AMEN1ADORA2A | |
| SCHEMBL5809944 | 0.68 | PDE4B (0.51) | PDE4BPDE4DKMT2AMEN1ADORA2A | |
| SCHEMBL5805731 | 0.68 | LMNA (0.62) | PDE4BPDE4DKMT2AMEN1ADORA2A | |
| SCHEMBL3253576 | 0.68 | PDE10A (0.55) | PDE10AKMT2AMEN1ADORA2AADORA1 | |
| SCHEMBL3369099 | 0.66 | MEN1 (1.00) | KMT2AMEN1ADORA2AADORA1ALDH1A1 | |
| SCHEMBL13849151 | 0.66 | ALDH1A1 (0.54) | KMT2AMEN1ADORA2AADORA1ALDH1A1 | |
| SCHEMBL7499394 | 0.65 | PDE4B (0.50) | PDE4BPDE4DALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |