Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064294 | 0.81 | TACR1 (0.54) | TACR1HSP90AA1HSP90AB1GRM5RIPK1 | |
| SCHEMBL6064290 | 0.81 | TACR1 (0.54) | TACR1HSP90AA1HSP90AB1GRM5RIPK1 | |
| SCHEMBL6550098 | 0.80 | TACR1 (0.53) | TACR1HSP90AA1HSP90AB1GRM5RIPK1 | |
| SCHEMBL30145299 | 0.76 | TACR1 (0.52) | TACR1HSP90AA1HSP90AB1GRM5RIPK1 | |
| SCHEMBL6311676 | 0.75 | TACR1 (0.36) | TACR1JAK2NTRK1 | |
| SCHEMBL6311681 | 0.75 | TACR1 (0.36) | TACR1JAK2NTRK1 | |
| SCHEMBL5811888 | 0.75 | TACR1 (0.36) | TACR1JAK2NTRK1 | |
| Maleic Acid SCHEMBL30145281 | 0.73 | TACR1 (0.47) | TACR1GRM5RIPK1 | |
| SCHEMBL5414345 | 0.72 | TACR1 (0.44) | TACR1 | |
| SCHEMBL4021108 | 0.72 | TACR1 (0.64) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638935-A1 | NK1 ANTAGONIST | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004110996-A1 | NK1 ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | disclosed |