Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145299 | 0.93 | TACR1 (0.52) | TACR1GRM5RIPK1ALDH1A1 | |
| SCHEMBL6064290 | 0.82 | TACR1 (0.54) | TACR1GRM5RIPK1 | |
| SCHEMBL6064294 | 0.82 | TACR1 (0.54) | TACR1GRM5RIPK1 | |
| SCHEMBL6550098 | 0.81 | TACR1 (0.53) | TACR1GRM5RIPK1 | |
| SCHEMBL5218238 | 0.79 | TACR1 (0.53) | TACR1GRM5RIPK1 | |
| SCHEMBL5811883 | 0.73 | TACR1 (0.43) | TACR1GRM5RIPK1 | |
| SCHEMBL13451348 | 0.69 | TACR1 (0.78) | TACR1 | |
| SCHEMBL5255105 | 0.69 | TACR1 (0.44) | TACR1 | |
| SCHEMBL5414345 | 0.69 | TACR1 (0.44) | TACR1 | |
| SCHEMBL4014194 | 0.68 | TACR1 (0.64) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220409599-A1 | USE AND COMPOSITION FOR PROTECTION AGAINST ORGANOPHOSPHORUS POISONING | CLARENCE SMITH KATHLEEN E (US) | 2022-12-29 | — | — | US | disclosed |